Last edited by Maulrajas
Monday, November 9, 2020 | History

2 edition of Immune Responses to Viral Vectors used in Gene Therapy found in the catalog.

Immune Responses to Viral Vectors used in Gene Therapy

Immune Responses to Viral Vectors used in Gene Therapy

Basic and Clinical Perspectives (Current Topics in Microbiology and Immunology)

by

  • 336 Want to read
  • 7 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Clinical & Internal Medicine,
  • Medical microbiology & virology,
  • Medical / Nursing,
  • Biochemistry,
  • Science,
  • Science/Mathematics,
  • Medical / Biochemistry,
  • Immunology,
  • Life Sciences - Genetics & Genomics

  • Edition Notes

    ContributionsMaria Castro (Editor), Hildegund Ertl (Editor), John Mountz (Editor), Pedro Lowenstein (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages240
    ID Numbers
    Open LibraryOL10152717M
    ISBN 100387287167
    ISBN 109780387287164
    OCLC/WorldCa144517661


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Immune Responses to Viral Vectors used in Gene Therapy Download PDF EPUB FB2

For Immune Responses to Viral Vectors used in Gene Therapy book purposes of gene therapy, one might either want to limit or expand the range of cells susceptible to transduction by a gene therapy vector. To this end, many vectors have been developed in which the endogenous viral.

Immune responses to viral vectors. Adenovirus (Ad) vectors were initially attractive for gene therapy applications because of their large packaging capacity, ability to efficiently transduce many non-dividing cell types and ease of production [].However, Ad vectors provoke a robust innate immune response Cited by:   Circumventing the immune response to the vector is a major challenge with all vector types.

Viral vectors are the most likely to induce an immune response, especially those, like Cited by: Title: Immune Responses to Adeno-Associated Virus Vectors VOLUME: 5 ISSUE: 3 Author(s):Anne K. Zaiss and Daniel A. Muruve Affiliation:University of Calgary, Hospital Drive N.W., Calgary, AB T2N 4N1, Canada.

Keywords:aav vector, innate immunity, adaptive immunity Abstract: One of the biggest challenges in optimizing viral vectors for gene therapy relates to the immune response Cited by: To move neurological gene therapy into the clinic in an effective and safe manner, these are the developments needed: novel viral vectors that either display a reduced capacity to stimulate an adaptive immune response or become invisible to the immune Cited by: The innovation of our research relates to 1) using natural viral immunomodulatory strategies to reduce unwanted host immune responses against gene therapy vectors and 2) developing novel.

Innate immunity to AAV vectors. Innate immune responses constitute the frontline defense against viral infections and the main toxicity feature encountered in the development of gene transfer strategies using adenoviral vectors.

27,28 AAV vectors, conversely, have gained wide acceptance as in vivo gene transfer vectors. Gene transfer technology has made considerable advances in targeting specific cell types and in the efficiency and regulation of transgene expression; nevertheless, a major obstacle for achieving stable therapeutic efficacy after in vivo LV gene therapy is the development of specific immune responses.

Attempts to correct genetic disorders by gene therapy have been hindered by various problems including unwanted immune responses against the gene product. It has been shown that immune responses. Cellular immune responses to adeno-associated viral (AAV) vectors used for gene therapy have been linked to attenuated transgene expression and loss of efficacy.

The impact of such cellular immune responses. Title: Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions VOLUME: 7 ISSUE: 5 Author(s):Pedro R.

Lowenstein, Ronald J. Mandel, Wei-dong Xiong, Kurt Kroeger and Maria G. Castro Affiliation:Gene. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below.

The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral. Alipogene tiparvovec (Glybera®) is an adeno-associated virus serotype 1 (AAV1)-based gene therapy that has been developed for the treatment of patients with lipoprotein lipase (LPL) deficiency.

Alipogene tiparvovec contains the human LPL naturally occurring gene variant LPLSX in a non-replicating viral vector based on AAV1. Such virus-derived vectors administered to humans elicit immune. Title:Nanoparticle Coated Viral Vectors for Gene Therapy VOLUME: 5 ISSUE: 1 Author(s):Ruchita Selot, Srujan Marepally, Praveen Kumar Vemula and Giridhara R.

Jayandharan Affiliation:Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur (U.P), India. Keywords:Gene therapy, nanoparticle, vector, immune response, hybrid delivery, gene.

These viral vectors are well suited for immunization strategies in which high, transient gene expression is needed to induce an immune response to the transduced cells. It is also possible to develop chimeric virus systems in which certain features of one viral system can be combined with features of a completely separate viral.

The technology entails engineering of viral vectors to express virus-neutralizing immunoglobulins or immunoglobulin-like proteins. Engineering T cell receptors and chimeric antigen receptors to recognize viral epitopes may be used to augment immune responses.

1. Introduction. Gene therapy provides new hope as a therapeutic method for both genetic and nongenetic diseases. Various types of gene delivery vectors have been developed to improve the efficiency of in vivo gene expression, and have been employed in many clinical trials.

The vectors for gene delivery are usually classified as viral or nonviral vectors. Adeno-associated virus is frequently used as a vector to deliver gene therapy, but most people are immune to it, rendering the therapy ineffective.

To bypass that mechanism, scientists in. Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and adaptive immune responses in mammalian hosts.

Currently, adenovirus vectors. Buy Immune Responses to Viral Vectors used in Gene Therapy: Basic and Clinical Perspectives (Current Topics in Microbiology and Immunology) on FREE SHIPPING on qualified orders. The lack of an apparent immune response to the nanoparticles is also a significant improvement over gene therapy with viral vectors.” The team is now working on using the nanoparticle system to treat patients with reduced or no vision due to genetic defects where blindness occurs because of a defective inherited gene.

Immune Attacks on Viral Vectors. Adeno-associated viruses (AAVs) are a popular choice to deliver DNA for gene therapies. But because these are commonly occurring viruses, some 70. The development of viral vectors for gene therapy has had an interesting and somewhat tumultuous history but remains the most important avenue tor treatment of a large number of diseases.

Gene Therapy; Viral Vectors; in inhibiting the immune response induced by AAV antibodies present as a result of natural immunity or following gene therapy.

anti-AAV antibodies in. Whether gene therapy using novel synthetic viral vectors to dampen the immune response would be both effective and safe in humans is a question that hasn’t been answered yet. Title: Immune Responses to Lentiviral Vectors VOLUME: 7 ISSUE: 5 Author(s):Antonia Follenzi, Laura Santambrogio and Andrea Annoni Affiliation:Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY, USA.

Keywords:Gene therapy, HIV-1 derived vectors, innate immunity, adaptive immune responses. Immune responses to factor IX (), a major concern in gene therapy for hemophilia, were analyzed for adeno-associated viral (AAV-2) gene transfer to skeletal muscle and liver as a function of the F9 underlying s identical to those recently used.

AstraZeneca ropes in Catalent gene therapy site to produce viral vectors for COVID vaccine. aims to induce a lasting immune response to spike proteins added to the virus's surface. Mechanisms of activation of innate and adaptive immune responses after typical viral infections have been summarized in Chapter 1.

There are many similarities to the ways in which gene transfer after administration of naked DNA or viral vectors. Here, the biology of and immune responses to intraocular injection of three different recombinant viral vectors – adenovirus, adeno-associated virus (AAV), and lentivirus – are summarized.

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy.

These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy. Viral vectors are potent gene delivery platforms used for the treatment of genetic and acquired diseases. However, just as viruses have evolved to infect cells efficiently, the immune.

Viral vectors are tools commonly used by molecular biologists to deliver genetic material into process can be performed inside a living organism or in cell culture ().Viruses have evolved. Therefore, adenovirus-based vectors can be used to transduce and deliver transgenes to different cell types including both replicating and quiescent cell populations.

This property of adenoviral vectors is extremely important in gene therapy and puts adenoviral vectors on top of viral vectors for gene. Purchase Nonviral Vectors for Gene Therapy, Volume 89 - 1st Edition.

Print Book & E-Book. ISBN  Gene Therapy Analytics and Manufacturing, a recent conference organized by the Cambridge Healthtech Institute and held in San Diego, described itself as a way to take “an in-depth.

Recombinant vectors can be used to deliver antigens and to stimulate immune responses in humans. Viral vectors possess various intrinsic properties which may lend to advantages and disadvantages for usage for a given therapeutic application [reviewed by Larocca and Schlom] [].The safety and flexibility of recombinant viral vectors have lead to their usage in gene therapy.

The UNC researchers then evolved new viral protein shells. Using serum from mice, rhesus monkeys, and humans, the researchers showed that the redesigned virus can slip past the immune system.

“This is the blueprint for producing AAV strains that could help more patients become eligible for human gene therapy. A wide range of vectors has been investigated for gene transfer to the cornea.

A number of viral vectors, in particular, have proved to be efficient at transducing the cornea and in association with a variety of transgenes, have been used. Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine.

Viral vectors. Many gene therapy approaches depend on viral vectors, which use a virus's natural ability to carry genetic material into cells. viruses create an immune response, which prevents .Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements.

In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral .First-generation (FG) adenoviral vectors (AdVs) have been widely used not only for gene therapy but also for basic studies.

Because vectors of this type lack the E1A gene that is essential for the expression of other viral .